LEUCEMIA GRANULOCITICA CRONICA PDF

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In most cases, there expression of the Philadelphia chromosome and production of an oncoprotein with enhanced tyrosine-kinase activity. The clinical course of the disease is characterized by three phases: chronic, accelerated and blast crisis. The diagnosis is established by clinical and hematological aspects. Among the main diagnostic methods, there is the complete blood count, the bone marrow examination and cytogenetic and molecular analyzes.

Amid the increasingly sensitive and specific methodologies, the complete blood countis an important tool as a screening method for new cases, especially when there are no characteristic symptoms. Some typical changes can be highlighted in the complete blood countis as a significant increase in leukocyte count, accompanied by increase in basophil count and the appearance of immature cells.

The treatment of choice is currently the quimioterapic imatinib mesylate, which have shown therapeutic success, resulting in decrease in the number of cases of evolution of chronic phase to accelerated phase. Rev Bras Hematol Hemoter. Bortolheiro Tc, Chiattone CS. Rev Bras Hematol Hemoter.. Acta Med Port. Bollmann Pw, Giglio A. Bain BJ. Porto Alegre: Artmed; Revista Brasileira de Cancerologia. Grando Ac, Wagner S. J Bras Patol Med Lab.

Porto Alegre: Artmed, Staging of chronic myeloid leukemia in the imatinib era. An evaluation of the World Health Organization proposal. Naoum PC.

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