Encephalitis lethargica. Its sequelae and treatment — Constantin Von Economo, front page The causes of encephalitis lethargica are uncertain. The early symptom would be dominated by sleepiness or wakefulness. A second symptom would lead to an oculogyric crisis. The third symptom would be recovery, followed by a Parkinson-like symptom.
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Encephalitis lethargica. Its sequelae and treatment — Constantin Von Economo, front page The causes of encephalitis lethargica are uncertain. The early symptom would be dominated by sleepiness or wakefulness. A second symptom would lead to an oculogyric crisis.
The third symptom would be recovery, followed by a Parkinson-like symptom. If patients of Stern followed this course of disease, he diagnosed them with encephalitis lethargica. Stern suspected encephalitis lethargica to be close to polio without evidence. Nevertheless, he experimented with the convalescent serum of survivors of the first acute symptom.
He vaccinated patients with early stage symptoms and told them that it might be successful. Stern is author of the s definitive book Die Epidemische Encephalitis and 2nd ed.
Stern was driven to suicide during the Holocaust by the German state, his research forgotten. Unfortunately, no: but inroads are certainly made here pertaining to diagnosis, pathology, and even treatment.
Albrecht of Hildesheim. Between and , Paris -based neurologist Jean-Martin Charcot documented many isolated cases of juvenile Parkinsonism , associated with diplopia , oculogyria , tachypnoea hyperventilation , retropulsion, tics , and obsessional disorders, which were almost certainly post-encephalitic in origin.
For the few survivors of the Nona, Parkinsonism and other sequelae developed in almost all cases. The encephalitis lethargica pandemic of —[ edit ] In the winter of —, a "new" illness suddenly appeared in Vienna and other cities, and rapidly spread world-wide over the next three years. Earlier reports appeared throughout Europe as early as the winter of —, but communication about the disease was slow and chaotic, given the varied manifestation of symptoms and difficulties disseminating information in wartime.
Encephalitis lethargica assumed its most virulent form between October and January The pandemic disappeared in as abruptly and mysteriously as it first appeared.
However, the majority of survivors subsequently developed neurological or psychiatric disorders, often after years or decades of seemingly perfect health. Post-encephalitic syndromes varied widely: sometimes they proceeded rapidly, leading to profound disability or death; sometimes very slowly; sometimes they progressed to a certain point and then stayed at this point for years or decades; and sometimes, following their initial onslaught, they remitted and disappeared.
Diagnosis[ edit ] There have been several proposed diagnostic criteria for encephalitis lethargica. One, which has been widely accepted, includes an acute or subacute encephalitic illness where all other known causes of encephalitis have been excluded. There is speculation that Adolf Hitler may have had encephalitis lethargica when he was a young adult in addition to the more substantial case for Parkinsonism in his later years.
Those described in the book Awakenings by the British neurologist Oliver Sacks. May 10, Wiener klinische Wochenschrift [Vienna clinical weekly] in German. Leipzig and Vienna: Franz Deuticke
Encefalitis letárgica, una temida enfermedad del pasado
Encephalitis lethargica Encephalitis epidemica und Grippeencephalitis. Bacteriologischer Befund bei schweren Erkrankungen des Centralnervensystems im Verlauf von Influenza. Some who shared his view nevertheless suspected that EL and influenza might be somehow related, just as measles and whooping cough were then regarded as allied disorders as they often occurred together in a population. They are fully aware of the situation, execute all requests promptly, get up when requested, walk about, but, if left to themselves, soon relapse into sleep. William Heinemann Medical Books ; London: In other cases the reply might be delayed an appreciable time, but shows clearly that the question was understood Hallp Influenza caused epidemic encephalitis encephalitis lethargica: There is, however, even stronger evidence for an etiological distinction: Baumann C, de Leeuw CH.